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KMID : 0388220100170040393
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Journal of the Korean Rheumatism Association
2010 Volume.17 No. 4 p.393 ~ p.399
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Clinical Significance of Serum C1q-Circulating Immune Complexes in Patients with Lupus Nephritis
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Kim Ju-Youn
Kim Sang-Hyun
Kim Hae-Rim
Park Sung-Hwan
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Abstract
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Objective: The purpose of this study was to evaluate whether serum C1q-circulating immune complexes (C1q-CIC) serve as a predictive marker for renal flares in patients with lupus nephritis.
Methods: Twenty-five patients with lupus nephritis and 24 healthy controls were enrolled. Patients with lupus nephritis had their serum C1q-CIC titers and other serologic parameters such as serum C3, C4, anti-dsDNA antibody, and erythrocyte sedimentation rate measured simultaneously. The systemic lupus erythematosus disease activity index (SLEDAI) was also checked.
Results: Serum C1q-CIC titers were higher in patients with lupus nephritis than in healthy controls (109.33±53.79 ?g/mL vs. 75.28±22.91 ?g/mL, p=0.008). A statistically significant association was found between serum C1q-CIC titers and C3 (p=0.011), C4 (p=0.027), and anti-dsDNA antibody (p=0.014). SLEDAI was also correlated with serum C1q-CIC titers (p=0.022).
Conclusion: Serum C1q-CIC appears to be related to renal disease activity in patients with lupus nephritis. These results suggest that serum C1q-CIC is a predictive marker for renal flares in patients with lupus nephritis.
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KEYWORD
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Lupus nephritis, C1q-Circulating Immune Complexes
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